Pollution-Related Asthma May Start in the Womb
Filed in archive Asthma on February 27, 2009
More and more studies link a child's risk of developing allergies and asthma to the conditions far back to when it was still in its mother's womb. According to a study published in PLoS ONE, children born in areas with increased traffic-related pollution may be at greater risk of developing asthma due to genetic changes acquired in the womb. An alteration to the baby's ACSL3 gene is associated with a mother's exposure to polycyclic aromatic hydrocarbons (PAHs), compounds that are byproducts of incomplete fuel combustion that accumulate to high levels in heavy-traffic areas.
Using biological specimens from the CCCEH birth cohort of mothers and children living in Northern Manhattan and the South Bronx, UC scientists analyzed umbilical cord white blood cell samples from 56 children for epigenetic alterations related to prenatal PAH exposure. (The mothers' exposure to PAHs was monitored during pregnancy using backpack air monitors).
The researchers found a significant association between changes in ACSL3 methylation-a gene expressed in the lung-and maternal PAH exposure. ACSL3 also was associated with a parental report of asthma symptoms in the children prior to age 5.
With confirmation in further studies, researchers say changes in the ACSL3 gene could serve as a novel biomarker for early diagnosis of pollution-related asthma.
If you live in the city, breathing polluted air daily, you need not wonder if you develop asthma. But it's amazing to see proof that pollution even affects a child still in the womb, setting it up to develop asthma later on. Sad, isn't it?
The researchers found a significant association between changes in ACSL3 methylation-a gene expressed in the lung-and maternal PAH exposure. ACSL3 also was associated with a parental report of asthma symptoms in the children prior to age 5.
With confirmation in further studies, researchers say changes in the ACSL3 gene could serve as a novel biomarker for early diagnosis of pollution-related asthma.
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Stephen
(03/03/09 9:21am)
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>>>>> PreEmptive > Metabolic Programming
> Against the OnSet of a LifeTime of ALLERGY Disease Progression.
We Can NOT Change our Genetic Pre-Disposition to ( Allergy ) Disease …
But We CAN Influence / Alter its COURSE.
Evidence reveals that Adult Illnesses which have long been blamed principally on
Genetic Influences or an UnHealthy LifeStyle > May instead be the Result of the INFANTs Uterine Environment.
Recent Findings
>> Traffic Pollution causes EpiGenetic ReProgramming Changes in the Womb
which increase a Child's Risk of developing Allergic Asthma.
"Our data supports the concept that environmental exposures can interact with genes during key developmental periods to trigger disease onset later in life, and that tissues are being reprogrammed to become abnormal later," said Dr Shuk-mei Ho, study leader and director of the Center for Environmental Genetics at the University of Cincinnati.
>> Mother’s Body train their Fetuses’ budding Immune Systems
U.C.S.F Research Group have discovered a surprising new mechanism by which Mom is helping to tune their Fetus / Infant’s Immune System early on.
> Whereby the Mother’s cells slip across the Placenta, enter the Fetus’s Body and teach it to treat these cells as its own. A crucial task of the developing immune system is to learn to distinguish between foreign substances and the self. It is tricky: the system must respond to outside threats but not overreact to harmless stimuli or the body’s own tissues.
In other words, the Nine Short Months of Life in the Womb may > Shape Your Baby’s Health > For as long as He or She Lives.
Further…
Chronic, UnResolved / UnTreated Inflammation
Spurred by an Immune System Over-Load
is now considered a Key Cause / Factor in almost all Chronic Degenerative and LifeStyle Diseases.
My Mother has Allergies / Allergic Asthma.
I have My Mother’s Allergies / Allergic Asthma.
How Can I STOP My Child from getting my ALLERGIES / Allergic ASTHMA ?
ALLERGY Disease is Strongly InHerited
The Child Allergy Apple Does Not Fall Far from the Parent Allergy Tree.
Statistics show that a child with one allergic parent has a 45-50% chance of developing allergies,
and the likelihood rises to between 65-70% if both parents have allergies.
Remarkably, even if both parents are allergy-free, offspring will still run an allergy risk of 10-15%.
ALLERGY = Immune System Over-Load = Chronic Inflammation = AutoImmune Diseases
1 in 3 Infants BEGIN Life Fighting the Progression of Allergy Disease.
“UnTreated” > ALLERGY Disease > Is a 24 / 7 / 365 / A LifeTime > Cumulative, Progressive, Chronic Inflammation, Auto-Immune Disease.
The Progression of Allergy March = Infant BIRTH > FOOD Allergy > Combo FOOD / Respiratory > Inhalant / Respiratory Allergy > Allergic ASTHMA
> A LifeTime of Unabated Disease Progression > Multi ReCalcitrant Diseases > Health Complications > Weakened Immune System & Compromised Quality of LIFE ( Ouch ! ).
If You could take PreEmptive Corrective Action to ALTER the Presence of ALLERGY Disease in Your Future Child …
Would YOU ?
OF Course !
> Break Your ALLERGY Legacy.
Prior to beginning Your Family… A visit to Your Primary Care Physician is the First Step.
Under your Personal Physician’s Care Management, each Allergy Patient undergoes an Allergy Examination and is Blood Tested ( Medical Insurance Covered ) for the most common Seasonal and Year-round Allergy Sources specific to their Geo-Region.
The GOAL of the Blood Test is not only to Identify which Allergens the Patient is Allergic to, but also, to establish the Degree of Patient Allergy Sensitivity to each Offending Allergen.
Once Your Offending Allergens / Allergy Profile has been Identified, Your Physician will Prescribe Your ALLERGY DROPs.
Good News ! > Allergy SHOTs have been Replaced by DROPs !
Your Self Administered, Under-the-Tongue Immuno-Allergy DROPS are Custom Formulated > following Clinical ImmunoTherapy Protocols and are designed to Neutralized specifically > What YOU Are Allergic To > Based on Your Allergy Test Result.
Slowly over Time, Your Allergy DROP Allergen Extract Concentrations are increased,
allowing Your Bodies Immune System to rely on its inherent recuperative abilities
and recalibrate itself, thereby neutralizing Your Allergies at the Disease Source,
No longer triggering Allergy Symptoms, Eradicating Allergy Complications and
Producing Lasting, if Not LifeTime Benefits !
Your DROPs are DRUG Free and so Safe that you will be able to continue your ImmunoTherapy Program into Pregnancy.
A > WIN for YOU.
A > WIN for your Future Child.
Visit Your Dr. Today and tell him / her that you want to Drop Your Allergies and Your Future Child’s.
Alter the Possibility of a LifeTime Progression of ALLERGY in Your Future Child.
It could be a CHILD’s LifeTime Difference ,
Between…
Being in the Game of LIFE
OR
Watching from the SideLines.
Respectively
Stephen
Principal of www.DropYourAllergies.com > Primary PHYSICIAN Diagnostics.com > Supporting Your “ Just Around the Corner” trusted Primary Care Dr. with Environmental and FOOD Allergy Testing, CUSTOM Formulated ImmunoTherapy ALLERGY DROPs and Custom FOOD Allergy DIET Plans.
>> Enviro / InHalant Allergy “Single Draw” Blood Testing specific to Your Geo-Region ( Insurance Covered )
>> IgE Immediate & IgG4 Delayed > FOOD Allergy Blood Testing ( Insurance Covered )
>> Patient Specific > Custom Formulated Enviro ImmunoTherapy Vaccine ( Under-the-Tongue DROPs or Injection )
>> FREE Patient Specific > Custom FOOD Allergy DIET Plans based on Your FOOD Allergy Test Result…