Folic Acid May Help Against Asthma and Allergies

Filed in archive Allergy: Research and Development on April 30, 2009

© Mrs. W.

A new study reviewing the medical records of more than 8,000 people ages 2 to 85 revealed that blood levels of folate, the naturally occurring form of folic acid, appears to be negatively correlated with asthma and allergies.

People with higher blood levels of folate had fewer IgE antibodies, fewer reported allergies, less wheezing and lower likelihood of asthma, researchers report.

"Our findings are a clear indication that folic acid may indeed help regulate immune response to allergens, and may reduce allergy and asthma symptoms," says lead investigator Elizabeth Matsui, M.D. M.H.S., pediatric allergist at Hopkins Children's. "But we still need to figure out the exact mechanism behind it, and to do so we need studies that follow people receiving treatment with folic acid, before we even consider supplementation with folic acid to treat or prevent allergies and asthma."

In detail, here are the findings:

• People with the lowest folate levels (below 8 nanograms per milliliter) had 40 percent higher risk of wheezing than people with the highest folate levels (above 18 ng/ml).
• People with the lowest folate levels had a 30 percent higher risk than those with the highest folate levels of having elevated IgE antibodies, markers of allergy predisposition.
• Those with the lowest folate levels had 31 percent higher risk of atopy (allergic symptoms) than people with the highest folate levels.
• Those with lowest folate levels had 16 percent higher risk of having asthma than people with the highest folate levels.

While there are still no studies directly showing the effect of dietary folate intake on allergies or asthma, I suppose it doesn't hurt to eat lots of green leafy veggies (which are rich in folic acid). At the very least, the vitamin boost will do the immune system good!